Complete Oil Specifications
Your 2022 Lexus RX 350 with the 3.5L 2GR-FKS V6 requires 0W-20 full synthetic oil meeting API SP / ILSAC GF-6A. The RX 350 is consistently one of the best-selling luxury SUVs in America, and its refined 2GR-FKS engine uses Toyota’s D-4ST dual injection system combining both port and direct injection.
Quick Reference
| Specification | Value |
|---|---|
| Viscosity | 0W-20 |
| API Rating | API SP |
| ILSAC Rating | GF-6A |
| Capacity (with filter) | 6.2 quarts |
| Oil Filter | Toyota/Lexus 90915-YZZN2 |
| Normal Interval | 10000 miles or 1 year |
Why 0W-20 for the 2GR-FKS
The 2GR-FKS is a sophisticated engine with Toyota’s D-4ST dual-injection system (combining port injection and direct injection). Variable Valve Timing with intelligence plus (VVT-iW) hydraulic cam phasers on both the intake and exhaust sides depend on rapid oil pressurization at startup. 0W-20’s thin cold-start viscosity protects these components before operating temperature is reached.
Using incorrect oil will:
- ❌ Delay pressurization of VVT-iW cam phasers
- ❌ Increase timing chain wear from delayed lubrication
- ❌ Risk voiding the Lexus warranty coverage
Lexus-Approved Oil Brands
-
✅ Lexus Genuine Motor Oil 0W-20
-
✅ Toyota Genuine Motor Oil 0W-20
-
✅ Mobil 1 Extended Performance 0W-20
-
✅ Pennzoil Ultra Platinum Full Synthetic 0W-20
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✅ Castrol Edge Full Synthetic 0W-20
Toyota and Lexus genuine oil is formulated specifically for these engines. Third-party oils must carry the API SP certification with ILSAC GF-6A starburst to meet the 2022 RX 350 specification.
Severe Service Check
Use the 5000 schedule if you:
- Tow a trailer or transport maximum load regularly
- Drive predominantly in urban stop-and-go traffic
- Operate in extreme climates — hot desert summers or sub-zero winters
- Drive on dusty, off-road, or unpaved surfaces
Installation Details
Drain Plug Torque: 27 ft-lbs
Replace the drain plug washer with each oil change — Lexus/Toyota uses a soft aluminum crush washer.
OEM Filter: Toyota/Lexus 90915-YZZN2
Aftermarket Filters:
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Mobil 1 M1-110A
-
WIX 57356
-
K&N HP-1010
Pro Tip: The 2GR-FKS holds 6.2 quarts — more than many owners expect from a V6. Verify oil level with the dipstick after the fill rather than relying on the pour count alone.
FAQs
What oil does a 2022 Lexus RX 350 take?
0W-20 full synthetic engine oil meeting API SP / ILSAC GF-6A.
How many quarts does the RX 350 need?
6.2 quarts with a new filter.
Why does the RX 350 V6 hold 6.2 quarts?
The 2GR-FKS is a 3.5L V6 with a larger-than-average sump to support its aluminum block design and extended oil life at Lexus’s 10,000-mile service interval. More oil volume means less thermal degradation between changes.
Can I use 5W-20 instead of 0W-20?
Lexus specifies 0W-20 for the 2022 RX 350. While both flow similarly above operating temperature, 0W-20 provides superior cold-start protection for the VVT-iW phasers. Only use 5W-20 as a last resort if 0W-20 is unavailable.
How often should I change the oil?
Every 10,000 miles or once per year with Lexus Genuine oil. Follow the Lexus Maintenance System reminders displayed in the instrument cluster.
Need these specs on your phone? Download OilFinderPro app for offline access and oil change reminders.
Last verified: 2026-02-27 | Source: 2022 Lexus RX Owner’s Manual (OM0G048U)