Complete Oil Specifications
Your 2022 Lexus RX 350 with the 3.5L 2GR-FKS V6 requires 0W-20 full synthetic oil meeting API SP / ILSAC GF-6A. The RX 350 is consistently one of the best-selling luxury SUVs in America, and its refined 2GR-FKS engine uses Toyota’s D-4ST dual injection system combining both port and direct injection.
Quick Reference
| Specification | Value |
|---|---|
| Viscosity | 0W-20 |
| API Rating | API SP |
| ILSAC Rating | GF-6A |
| Capacity (with filter) | 6.2 quarts |
| Oil Filter | Toyota/Lexus 90915-YZZN2 |
| Normal Interval | 10000 miles or 1 year |
Why 0W-20 for the 2GR-FKS
The 2GR-FKS is a sophisticated engine with Toyota’s D-4ST dual-injection system (combining port injection and direct injection). Variable Valve Timing with intelligence plus (VVT-iW) hydraulic cam phasers on both the intake and exhaust sides depend on rapid oil pressurization at startup. 0W-20’s thin cold-start viscosity protects these components before operating temperature is reached.
Using incorrect oil will:
- ❌ Delay pressurization of VVT-iW cam phasers
- ❌ Increase timing chain wear from delayed lubrication
- ❌ Risk voiding the Lexus warranty coverage
Lexus-Approved Oil Brands
-
✅ Lexus Genuine Motor Oil 0W-20
-
✅ Toyota Genuine Motor Oil 0W-20
-
✅ Mobil 1 Extended Performance 0W-20
-
✅ Pennzoil Ultra Platinum Full Synthetic 0W-20
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✅ Castrol Edge Full Synthetic 0W-20
Toyota and Lexus genuine oil is formulated specifically for these engines. Third-party oils must carry the API SP certification with ILSAC GF-6A starburst to meet the 2022 RX 350 specification.
Severe Service Check
Use the 5000 schedule if you:
- Tow a trailer or transport maximum load regularly
- Drive predominantly in urban stop-and-go traffic
- Operate in extreme climates — hot desert summers or sub-zero winters
- Drive on dusty, off-road, or unpaved surfaces
Installation Details
Drain Plug Torque: 27 ft-lbs
Replace the drain plug washer with each oil change — Lexus/Toyota uses a soft aluminum crush washer.
OEM Filter: Toyota/Lexus 90915-YZZN2
Aftermarket Filters:
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Mobil 1 M1-110A
-
WIX 57356
-
K&N HP-1010
Pro Tip: The 2GR-FKS holds 6.2 quarts — more than many owners expect from a V6. Verify oil level with the dipstick after the fill rather than relying on the pour count alone.
FAQs
What oil does a 2022 Lexus RX 350 take?
0W-20 full synthetic engine oil meeting API SP / ILSAC GF-6A.
How many quarts does the RX 350 need?
6.2 quarts with a new filter.
Why does the RX 350 V6 hold 6.2 quarts?
The 2GR-FKS is a 3.5L V6 with a larger-than-average sump to support its aluminum block design and extended oil life at Lexus’s 10,000-mile service interval. More oil volume means less thermal degradation between changes.
Can I use 5W-20 instead of 0W-20?
Lexus specifies 0W-20 for the 2022 RX 350. While both flow similarly above operating temperature, 0W-20 provides superior cold-start protection for the VVT-iW phasers. Only use 5W-20 as a last resort if 0W-20 is unavailable.
How often should I change the oil?
Every 10,000 miles or once per year with Lexus Genuine oil. Follow the Lexus Maintenance System reminders displayed in the instrument cluster.
Last verified: 2026-02-27 | Source: 2022 Lexus RX Owner’s Manual (OM0G048U)